Fig. 2: Examples of polymer-based fixed-target devices.
From: Sample delivery methods for protein X-ray crystallography with a special focus on sample consumption
a Fixed-target system developed by Martiel et al.101 where a microporous COC membrane (3 µm) was developed as a sample support. This panel shows an image of the device mounted on a holder and a scanning electron microscope (SEM) image of the pores on the COC membrane. Schematics of the filling process are also shown, where devices were filled from the well-side and excess mother liquor was removed from the bottom using blotting paper. Reprinted with permission from IUCrJ. b Polyimide-based fixed-target system developed by Nam et al.111, which contained a polyimide mesh with irregularly shaped holes (shown in red rectangular inset). A mesh was enclosed between two polyimide films to prevent crystal dehydration. c A fixed-target system developed by Shelby et al.122 in combination with graphene to prevent the dehydration of samples. This panel shows the schematics of a cross-sectional view of the assembled device. Reprinted with permission from IUCrJ. d A rotation-based fixed-target system developed by Zhao et al.124. This panel demonstrates the overall design of the device. Reprinted with permission from IUCrJ.
