Fig. 6: AFM-IR nano-chemical analysis of FUS and FUS + DNAJB6 condensates. | Nature Communications

Fig. 6: AFM-IR nano-chemical analysis of FUS and FUS + DNAJB6 condensates.

From: Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity

Fig. 6: AFM-IR nano-chemical analysis of FUS and FUS + DNAJB6 condensates.

a Maps of 3D morphology. b IR average spectra from 3 independent condensates and second derivative of the amide I band to deconvolve protein secondary structure contributions. a.u. is arbitrary units. c Quantification of secondary structure. Quantification of secondary structure. Data are shown as integration of the area of the second derivative spectra that is used for the determination of the average secondary structure ± the error of area integration for three biological replicates. FUS, n > 100 spectra; FUS + DNAJB6, n > 80 spectra.

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