Fig. 3: Prefrontal–BNST theta biomarkers and neuropsychological predictors. | Nature Communications

Fig. 3: Prefrontal–BNST theta biomarkers and neuropsychological predictors.

From: Prefrontal–bed nucleus of the stria terminalis physiological and neuropsychological biomarkers predict therapeutic outcomes in depression

Fig. 3: Prefrontal–BNST theta biomarkers and neuropsychological predictors.The alternative text for this image may have been generated using AI.

a Correlation matrix between theta band Granger causality and 3-month clinical improvements (n = 17). *FDR adjusted p < 0.05 for Spearman’s correlation (two-sided). b Fiber tracts (blue) related to lower BNST theta power (predicting better clinical outcomes) overlaid with fiber tracts from the open-source tracts available for optimal OCD DBS targets (red). c Correlation map (n = 17) between symptom severity at baseline, 3-month treatment response and affective ratings (arousal and valence). *Unadjusted p < 0.05, **Unadjusted p < 0.01, ***Unadjusted p < 0.001 for Spearman’s correlation (two-sided). HAMD Hamilton Depression Scale, HAMA Hamilton Anxiety Scale, MADRS Montgomery-Asberg Depression Rating Scale, DARS Dimensional Anhedonia Rating Scale, 3M 3 months, BNST bed nucleus of the stria terminalis, GC Granger Causality, NegValence negative valence, PosValence positive valence, NegArousal negative arousal, PosArousal positive arousal.

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