Fig. 3: DNA methylation analysis reveals distinct clusters of hepatic NEN, HCC and CCA.
From: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms
A t-SNE plot of the DNA methylation profiles of CCA (N = 27), HCC (N = 50), hepatic NEN (N = 22), NEN liver metastases (N = 22), non-neoplastic (normal) liver (N = 50) and normal bile duct tissue samples (N = 50) showing a clear separation of hepatic NEN from HCC, CCA and non-neoplastic samples (N = 50). B t-SNE plot with indication of hepatic NEN and NEN liver metastases with low (<3%), intermediate (3–20%) or high (>20%) percentage of Ki67-positive tumor cells. CCA cholangiocarcinoma, HCC hepatocellular carcinoma.
