Fig. 6: Hepatic NEN of the independent validation cohort from Beaujon University Hospital.
From: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms
A Overview of patient selection process for the independent validation cohort from Beaujon University Hospital (Paris, France). B–D t-SNE plots of the DNA methylation profiles of the hepatic NEN from Beaujon (N = 15) and Heidelberg University Hospitals (N = 22) and of the NEN reference cohort (N = 153) including Merkel cell carcinoma (N = 14 of 11 patients), appendiceal NEN (N = 15), ileal NEN (N = 18), gastric/duodenal (N = 14), colorectal NEN (N = 18), pancreatic NEN (N = 25), pulmonary carcinoids (N = 25) and pulmonary NEC (N = 24). (C). Hepatic NEN from Beaujon predicted as pulmonary carcinoids and hepatic NEN from Heidelberg predicted as pulmonary NEC, together with pulmonary carcinoids (N = 25) and pulmonary NEC (N = 24) of the reference cohort are highlighted in color. D Hepatic NEN from Beaujon and Heidelberg University Hospitals predicted as gastric/duodenal NEN or as colorectal as well as the reference groups of colorectal NEN and gastric/duodenal NEN are highlighted in color.
