Fig. 2: Catalyst development and ligand parameterization. | Nature Communications

Fig. 2: Catalyst development and ligand parameterization.

From: Enantiotopic-group-selective coupling for unified access to carbazole atropisomers as versatile chiral chromophores

Fig. 2

A Survey of phosphine ligands. B Stereoinduction model based on absolute configurations, steric property map of L6, and parameterization analysis for ligands. Reaction conditions: 1 (0.1 mmol), PMP-B(OH)2 (0.12 mmol), K3PO4 (0.5 mmol), Pd2dba3 (1.0 mmol%), Ligand (2.0 mmol%), THF (20 mL/mmol), H2O (1.4 mL/mmol), 60 oC, 18 h. Enantiomeric ratio (er) was determined using HPLC–CSP. dba dibenzylideneacetone, Cy cyclohexyl, Me methyl, Ph phenyl, Pr propyl, PMP p-methoxyphenyl, THF tetrahydrofuran.

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