Fig. 7: IL-18Rαhi CD8 T cells are highly polyfunctional. | Nature Communications

Fig. 7: IL-18Rαhi CD8 T cells are highly polyfunctional.

From: High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures

Fig. 7

a Frequency of IFNγ-secreting IL-18Rαhi and IL-18Rαlo CD8 T cells in the lung and spleen was analysed ex vivo 10 dpi after peptide stimulation with immunodominant NP366 and PA224 peptides. b Comparison of TNF+ producers in IFNγ+IL-18Rαhi and IL-18Rαlo CD8 T cells populations. c Frequencies of IL-2+ of IFNγ+TNF+CD8+IL-18Rαhi and IL-18Rαlo T cells. Data were analysed using a two-tailed paired t-test (n = 15). d Polyfunctional profiles (IFNγ, TNF, IL-2) of IL-18Rαlo and IL-18Rαhi CD8 T cells after peptide stimulation in the lungs and spleen. Data were analysed via a permutation test. Data shown are from three independent experiments.

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