Fig. 8: Inverse correlations between IL-18Rα and cytotoxic T cell signatures associated with severe disease outcomes in human A/H7N9 and COVID-19 cohorts. | Nature Communications

Fig. 8: Inverse correlations between IL-18Rα and cytotoxic T cell signatures associated with severe disease outcomes in human A/H7N9 and COVID-19 cohorts.

From: High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures

Fig. 8

Correlations between IL18R1 expression and GZMA (Granzyme A), GZMB (Granzyme B), PRF1 (Perforin 1), EOMES, KLRG1 and CX3CR1 were analysed in our A/H7N9 and COVID-19 datasets. a, b Associations between GZMA (p = 8.5e-09), GZMB (p = 0.03), PRF1 (p = 1.4e-06), EOMES (p = 2.2e−16), KLRG1 (p = 6.1e−10) and CX3CR1 (p = 1.5e−08) expression levels with disease severity was also analysed. c Significant correlations with IL18R1 expression and disease severity for differentially expressed genes from our OT-I experiment (Fig. 4), namely IL1R1L1, TIGIT, IL10RA and XCL1. R = spearman’s correlation (two-tailed), where * = p < 0.05 l;** = p < 0.01; *** = p < 0.001. Box plot hinges are the first and third quartiles (the 25th and 75th percentiles). The line between hinges corresponds to the median. The upper whisker extends from the hinge to the largest value no further than 1.5 * IQR from the hinge (where IQR is the inter-quartile range, or distance between the first and third quartiles). The lower whisker extends from the hinge to the smallest value at most 1.5 * IQR of the hinge.

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