Fig. 1: Association between selection for MHC I diversity and cancer mortality risk across mammals.

Non-zero a CMR or b ICM were plotted against selection for MHC I diversity at the 20 most positively selected sites (PSS), expressed as the ratio of non-synonymous (dN) to synonymous (dS) nucleotide substitution rates. Points are proportional to the precision of cancer mortality risk estimates (as indicated by the total number of individuals with RDI). Slopes originate from phylogenetic models using a consensus tree (presented in Table S2) and both associatons were statistically significant p = 0.0034 and 0.0436, respecitvely). All models were repeated with 100 equally likely phylogenetic hypotheses and the distribution of p-values indicating the relationship between selection for MHC I diversity and c CMR or d ICM are shown. P = 0.05 is marked with a vertical red line. All statistical tests performed are two-sided and no correction for multiple testing was performed.