Fig. 4: 53BP1 loss and DNA-PKcs disruption, alone and together, cause a similar increase in microhomology usage for deletions. | Nature Communications

Fig. 4: 53BP1 loss and DNA-PKcs disruption, alone and together, cause a similar increase in microhomology usage for deletions.

From: 53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes

Fig. 4

Shown is the frequency of microhomology used amongst deletions for each experimental condition shown in (Fig. 2C). Frequencies represent the mean ± SD. n = 3 biologically independent transfections. Statistics with an unpaired t-test using Holm–Sidak correction. *left to right P = 0.021376, P = 0.044904, P = 0.013506, **left to right P = 0.001454, P = 0.009389, P = 0.003635, P = 0.007368, P = 0.006555, ***left to right P = 0.000556, P = 0.000556, P = 0.000289, P = 0.000728, P = 0.000363, P = 0.000671, P = 0.000332, P = 0.000158, ****P < 0.0001, n.s. = not significant. Source data are provided as a Source data file.

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