Fig. 2: Examples of regions with notable allele-specific methylation patterns in placenta.

From the top down, each panel shows the genomic coordinates, relevant annotations, translation from genomic space into CpG-only space, and a smoothed methylation plot at the bottom. The C19MC locus (a) contains many paternally-expressed (Supplementary Fig. 7) and paternally-demethylated pri-miRNA loci and is among the best known examples of a placental DMR. Here we can see the pattern of differential methylation across the locus. The SST1/MER22/NBL2 macrosatellite array (b), also on chromosome 19, is a previously unreported example with a periodic pattern of DMRs corresponding to the SST1 repeats, originating at a HERVH element upstream of the array. This locus is also paternally expressed, as shown in Supplementary Fig. 8.