Fig. 5: EE modulates chromatin accessibility and DNA methylation in subsets of granule neurons enhancers.
From: Neuronal type-specific modulation of cognition and AP-1 signaling by early-life rearing conditions
A Heatmap of DARs in ATAC-seq profiles of DG SUN1-GFP+ neurons in IE, SC and EE conditions (padj <0.1). n = 3 samples per rearing condition. B Pearson correlation between the fold change in chromatin accessibility and the fold change in H3K27ac levels when comparing EE vs SC (left) and IE vs SC (right), within DG (top) and CA1 (bottom) excitatory neurons enhancers. C PCA of DNA methylation profiles of CA1 (top) and DG (bottom) SUN1-GFP+ neurons in IE, SC an EE conditions. n = 2 samples per region per rearing condition. D The number of DMRs and the associated DEGs for each comparison are shown. E Pie charts representing the fraction of DMRs overlapping with CA1 and DG promoters and enhancers for each comparison. DMRs not overlapping with either were classified as “others”.
