Fig. 4: Cross mapping of PL neurons recorded during satiation and threat tests. | Nature Communications

Fig. 4: Cross mapping of PL neurons recorded during satiation and threat tests.

From: Divergent prefrontal cortex circuits regulate cued food seeking under distinct metabolic or emotional states

Fig. 4

a Left, schematic of microendoscopic imaging; Right, representative image of neurons from one animal that are recorded only during the satiation test (green), only during the threat test (pink), or cross-mapped in both tests (yellow). Schematic created in BioRender. Zhang, X. (2025) https://BioRender.com/30ckzl8. b–e Heatmaps showing food-cue responses of all cross-mapped neurons (n = 395) in each state, with a rank order based on the cue responses during hungry states. f Heatmap (top) and averaged traces (bottom) of different clusters of neurons showing similar or distinct dynamics during food-cue presentation in hungry vs. safe test. Red dashed box highlights a cluster that shows similar food-cue responses in hungry and safe states. Inset: area under the curve within 1.5 s after cue onset (AUC 1.5 s) for all neurons in cluster 8. Two-sided Wilcoxon’s signed-rank test. g Heatmap (top) and averaged traces (bottom) of different clusters of neurons showing similar or distinct dynamics during food-cue presentation in satiated vs. threat test. *p < 0.05. Data in f and g bottom shown as mean ± SEM. Box plot centre line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range; points, outliers. Source data are provided as a Source Data file.

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