Fig. 6: ABHD11 inhibition impairs the function of antigen-specific T-cells.
From: Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function
a Frequency of proliferating cells, as determined using CFDA-SE, on antigen-specific T-cells (n = 4). b Surface expression of activation markers (CD25 and CD69) on antigen-specific T-cells (n = 4). c IFNγ, IL-2, IL-10, IL-17 and TNFα production by antigen-specific T-cells (n = 4). All experiments were carried out using murine samples. BDC2.5 CD4+ T-cells were activated with hybrid insulin peptides (HIPs), in the presence and absence of WWL222. Data are expressed as mean. Statistical tests used: two-way ANOVA with Šidák’s multiple comparisons test (a, b), multiple two-tailed unpaired t-test (c). Source data are provided as a Source Data file.
