Fig. 2: TR-SAXS and 2D 1H-15N-HMQC NMR showing the primary condensation kinetics and interactions between Tau and αS with spermine. | Nature Communications

Fig. 2: TR-SAXS and 2D 1H-15N-HMQC NMR showing the primary condensation kinetics and interactions between Tau and αS with spermine.

From: Spermine modulation of Alzheimer’s Tau and Parkinson’s α-synuclein: implications for biomolecular condensation and neurodegeneration

Fig. 2

A Schematic illustration of microfluidic device with 3 channels. B the Rg distribution of Tau alone and Tau with spermine within 0.92 s (n = 50). C the Rg distribution of αS alone and αS with spermine within 0.92 s (n = 50). D Spectra of 15N-Tau in the absence and presence of spermine in PBS buffer pH 6.3. In the right panel is the chemical shift changes from the spectra presented as a function of the residue number in the protein primary sequence. The spectra were recorded at 283 K. Full spectra are shown in Figure S14. Data are presented as mean values +/− SEM.

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