Fig. 1: CHAIN LPS study workflow. | Nature Communications

Fig. 1: CHAIN LPS study workflow.

From: Plasma lipopolysaccharide levels predict mortality in acutely ill children in Low- and Middle-Income Countries

Fig. 1: CHAIN LPS study workflow.

The study analyzed data from 638 children from the CHAIN nested case-cohort (CHAIN NCC, details21) who were admitted to the hospital (admissions) and 251 well children from the same neighborhoods as the admissions cohort (community). Overall, these children were from 9 sites across 6 countries in Sub-Saharan Africa and South Asia. This study includes data from LPS and SomaScan proteomics in plasma, markers for enteric dysfunction measured in stool, and TaqMan Array Card (TAC) enteropathogen data from fecal swabs. Plasma LPS data were also available for 495 cohort children at hospital discharge. Analyses included evaluation of plasma LPS levels, medical conditions, hospitalization, survival, plasma proteomics and deconvolution of a single-cell transcriptomic dataset. Abbreviations: LPS lipopolysaccharide, NCC nested case-cohort. Created in BioRender. Allen, C. (2025) https://BioRender.com/q3bom29.

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