Fig. 3: Correlation of proteins and their associations with plasma LPS and 90-day survival in LPShi Fatal sub-group.
Correlograms depicting the associations of A plasma LPS and B 90-day survival with the strongest of correlations with SomaScan proteins detected in the LPShi Fatal sub-group (n = 39). Correlation matrices were inverse-proportionally weighted to account for selection biases. Correlograms were hierarchically clustered using the ‘ward.D2’ method. Each circle represents the Pearson’s correlation coefficient (r), with color intensity indicating the strength of the correlation. Positive correlations are shown in red, and negative correlations are shown in blue. Only correlations with an absolute value of r ≥ 0.4 are displayed, highlighting moderate to high associations (see Supplementary Table 12). Additionally, only coefficients with a two-tailed p-value < 0.05 are shown; coefficients with p-value ≥ 0.05 are represented as blank, white circles. All p-values were adjusted for false discovery rates using the Benjamini–Hochberg (BH) method, based on the full SomaScan dataset of over 7300 proteins. All n values refer to independent children; no technical replicates were used.
