Fig. 4: Top differentially expressed proteins in the LPShi Fatal sub-group.
Proteins of the insulin-like growth factor nutritional axis, inflammation and collagen regeneration are the top 10 up or downregulated proteins in the LPShi F sub-group, as identified by log2 fold change of expression between LPShi F sub-group (n = 39) and community children (n = 251). All proteins had significantly different expression (two-tailed p < 0.05) as assessed by the Wilcoxon signed-rank test and were Holm-adjusted for multiple comparisons. There was a significantly different expression of these 20 plasma proteins in the LPShi F compared to other LPS sub-groups. The x-axis denotes the LPS sub-groups, while the y-axis represents protein expression in units of Log2 transformed (RFU + 1). Central tendencies are shown as large dots representing mean ± standard deviation (SD), while individual values for each child are indicated by small dots. Models adjusted for sex, age, site, and HIV status confirmed differential expression for the majority of identified proteins (Supplementary Tables 18 and 19). RFU relative fluorescence units. All n values refer to independent children; no technical replicates were used. F fatal, NF non-fatal.
