Fig. 5: Differentially abundant plasma proteins in LPShi Fatal cohort indicate a cross-talk between immune and intestinal cell types.
Evaluation of proteomic expression of LPS sub-groups (LPShi F (n = 39), LPSlo F (n = 125), LPShi NF (n = 46) and LPSlo NF (n = 425)) identified proteins that were differentially abundant in the LPShi F sub-group. All analyses of LPS sub-groups were performed against identical community children (n = 251). Heatmap visualizes A membrane-derived or B soluble plasma proteins, where directionality of Log2 fold change (vs. community children) was opposite in the LPShi F sub-group compared to the other 3 sub-groups. A, B Differentially abundant proteins had significant differences in expression (two-tailed p < 0.05) in at least one LPS sub-group. C Dot plot of the genes that encode membrane-derived and soluble plasma proteins with differential directional expression in the LPShi F group (vs. community children) compared to expression in the other 3 groups (LPShi NF, LPSlo F and LPSlo NF) (vs. community children). All n values refer to independent children; no technical replicates were used. F fatal, NF non-fatal.
