Fig. 8: AMP 1003 exerts promising therapeutic potential in MRSA- or K. pneumoniae-infected pneumonia models.

a Flowchart of the bacterial pneumonia experiment. CYP stands for cyclophosphamide. b Bacterial load (in terms of CFU/mL) in the lung homogenate of MRSA ATCC 33591-infected pneumonia mouse model treated with saline, 1003 (5 mg/kg or 10 mg/kg), or Van (5 mg/kg). Van stands for vancomycin, n = 6 mice per group. Data are presented as mean values ± SD. Data points show the individual values, the central line represents the median, and the error bars indicate the range. Statistical analysis: two-tailed t-test. c Pathological sections stained by H&E of the lung in the MRSA ATCC 33591-infected pneumonia mouse model treated with saline, 1003 (5 mg/kg or 10 mg/kg), or Van (5 mg/kg), Van stands for vancomycin, n = 3 mice per group. Scale bar: 100×: 200 μm, 200×: 100 μm, 400×: 50 μm. d Bacterial load (in terms of CFU/mL) in the lung homogenate of K. pneumoniae ATCC 700603-infected pneumonia mouse model treated with saline, 1003 (5 mg/kg or 10 mg/kg), or Pob (5 mg/kg). Pob stands for polymyxin B, n = 6 mice per group. Data are presented as mean values ± SD. Data points show the individual values, the central line represents the median, and the error bars indicate the range. Statistical analysis: two-tailed t-test. e Pathological sections stained by H&E of the lung in the K. pneumoniae ATCC 700603-infected pneumonia mouse model treated with saline, 1003 (5 mg/kg or 10 mg/kg), or Pob (5 mg/kg), Pob stands for polymyxin B, n = 3 mice per group. Scale bar: 100×: 200 μm, 200×: 100 μm, 400×: 50 μm. Source data are provided as a Source Data file.