Fig. 4: Proposed consensus model of integrin-mediated TGF-β activation. | Nature Communications

Fig. 4: Proposed consensus model of integrin-mediated TGF-β activation.

From: Latent-TGF-β has a domain swapped architecture

Fig. 4

Proposed model of continuous deformation of L-TGF-β upon αvβ6 binding, based on L-TGF-β contralateral domain architecture, from intact latent ring with minimum deformation (left) towards fully deformed ring allowing mature TGF-β to be released (right). Increased deformation of L-TGF-β correlates with increased exposure of mature TGF-β to its receptors, from unreleased for autocrine signaling to the released form for paracrine signaling. Integrin cartoons are created in BioRender. Nishimura, S. (2025) https://BioRender.com/29k4zvb.

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