Fig. 4: Results from Searchlight RSA Analysis with Hmax-C1 and Categorical Model. | Nature Communications

Fig. 4: Results from Searchlight RSA Analysis with Hmax-C1 and Categorical Model.

From: Impact of a transient neonatal visual deprivation on the development of the ventral occipito-temporal cortex in humans

Fig. 4

The top row presents results from the searchlight analysis within each group and condition: controls (A), Cataract-reversals (B), Controls-blurry exp 1 (C), and Controls-blurry exp 2 (D). Within each panel, Spearman’s r of brain dissimilarity with the Hmax-C1 model is depicted on the left, and Spearman’s r with the categorical model is depicted on the right. Below the brain maps, representational dissimilarity matrices (RDMs) extracted from significant clusters are displayed. The second row presents between-group contrasts: Controls > Cataracts (E), Controls > ConBlurry1 (F), and Controls > ConBlurry2 (G). H shows the two representational models: Hmax-C1 (left) and categorical (right). I, J show Cataract > ConBlurry1 and Cataract > ConBlurry2, respectively. For each subject and searchlight sphere (100 voxels), representational dissimilarity matrices (RDMs) were computed from stimulus-specific activation patterns and compared with the two models using Spearman’s partial correlation, regressing out shared variance between models. Correlation values were Fisher-transformed and entered into one-sample t-tests (within groups, two-sided) and two-sample t-tests (between groups, two-sided). Group contrasts were corrected for multiple comparisons using threshold-free cluster enhancement (TFCE) with family-wise error (FWE) correction applied within independent masks: V1 for the Hmax-C1 model, VOTC for the categorical model. Maps are displayed at p < 0.05 FWE corrected. For regions showing significant group differences, RDMs from both groups and their correlations with the two models are shown alongside dot plots. Dot plots are presented for visualization only and are not statistically tested to avoid circularity. Dot plots display individual subject data (independent biological replicates; n = 16 Controls in orange, n = 14 Cataract in green, n = 14 ConBlurry1 in light purple, n = 14 ConBlurry2 in dark purple) with mean ± SEM. Source data for dot plots are provided as a Source Data file. Contrasts without suprathreshold voxels are not shown. BrainNet Viewer was used for the visualization of brain maps120.

Back to article page