Fig. 2: Comparison of gene expression changes between Proband 1 and knockout MEFs. | Nature Communications

Fig. 2: Comparison of gene expression changes between Proband 1 and knockout MEFs.

From: A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome

Fig. 2

a Gene ontology analysis for biological processes (BP) and molecular functions (MF) on Proband 1 up and down-regulated genes (zScore > 2) identified by RNAseq. Significant pathways were calculated using a classic one-sided Fisher exact test with a cut-off <0.01. The top 10 pathways are plotted. b Heatmap comparing the log2 fold change of Proband 1 genes (zScore >2) and the same genes in the knockout MIDEAS mouse embryonic fibroblast dataset (fold change limit set to -0.5 – 0.5 to aid visualisation). c Overall correlation of fold changes of Proband 1 genes (zScore >2) vs the same genes in the knockout MIDEAS mouse embryonic fibroblast dataset (MEF_MIDko). d Fold change of overlapping genes in both Proband 1 and MIDEAS KO MEF datasets.

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