Fig. 3: Structure of the MiDAC dimer to 2.9 Å. | Nature Communications

Fig. 3: Structure of the MiDAC dimer to 2.9 Å.

From: A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome

Fig. 3

a,b View of the overall combined focussed map with a cartoon representation of the MiDAC complex. HDAC1 is shown in grey, MIDEAS orange, DNTTIP1 in purple and pink. Map contour level is 10 in Chimera. c The N-terminal tail of DNTTIP1 (shown as a purple cartoon and sticks) forms a loop and interacts in a groove in MIDEAS (shown as an orange surface). d Interaction of DNTTIP1 T35 to M41 with the MIDEAS ELM2 and SANT domains (shown in the map). e N-terminal loop of DNTTIP1 from H44 to H57 (shown in the map). f Interaction of MIDEAS P653 to Y670 with HDAC1 showing the potential inhibition of HDAC1 by I659 in the active site (shown in the map). g The active site of HDAC1 (grey) highlighted by an arrow is sterically hindered by MIDEAS. MIDEAS and HDAC1 are shown as a surface and DNTTIP1 is shown in sticks. h Interaction of MIDEAS P653 to Y670 with HDAC1 showing the interaction of Y654 MIDEAS with P721 and P656 (shown in the map). i T655 of MIDEAS interacts with N95 and E146 of HDAC1 (shown in the map). Map contour level is 9 in Pymol.

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