Fig. 4: Ligand-receptor pairs between BECs and astrocyte endfeet and their modulation during peripheral inflammation.
From: Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human
a Diagram of the search criteria for ligand-receptor pair identification. Ligand-receptor pairs were considered when ligands were found in BEC RNA-seq data and a corresponding receptor was found in the endfoot proteome. b Venn diagram showing overlap of identified ligand-receptor pairs from mice at baseline (gray, PBS BEC IP > 1 FPKM and PBS endfoot proteome), downregulated by LPS (purple, BEC log2(LPS/PBS) < −1, FDR < 0.05 and PBS + LPS endfoot proteome), or upregulated by LPS (red, log2(LPS/PBS) > 1, FDR < 0.05 and PBS + LPS endfoot proteome). c–e Sankey plots illustrating interactions between ligand-receptor pairs found to be downregulated (c), upregulated (d), or induced by LPS (i.e., only present in the LPS condition; e) Source data are provided in Supplementary Data 7.
