Fig. 3: Signaling pathways differentially regulating function in each synaptic type from the trisynaptic circuit. | Nature Communications

Fig. 3: Signaling pathways differentially regulating function in each synaptic type from the trisynaptic circuit.

From: Synaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins

Fig. 3: Signaling pathways differentially regulating function in each synaptic type from the trisynaptic circuit.The alternative text for this image may have been generated using AI.

Signaling pathways overrepresented amongst DE proteins in each synapse of the trisynaptic loop. Pathways specific to CA3-CA1 synapses are framed in a blue box, pathways specific to DG-CA3 in a green box, those common to these 2 in a yellow box and, finally, pathways specific to EC-DG synapses are in an orange box. Relative protein abundance for each of the 9 samples investigated by LC-MS/MS are presented as z-scores in heatmaps. A title and a heatmap is presented for each overrepresented pathway. Related pathways (i.e. CA3-CA1 pathways involved in Energy Metabolism) are framed with a dashed black line. For some pathways (i.e. Traffic of A2-containing AMPARs), we also present a heatmap with proteins that have a clear DE but did not reach statistical significance (Not Significant). In the ‘Rhos Activate Wasps and Waves’ gene names of members of the Arp2/3 complex are in bold.

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