Fig. 4: Differentially expressed synaptic genes mostly regulate neurotransmitter receptor function and synaptic vesicle exocytosis. | Nature Communications

Fig. 4: Differentially expressed synaptic genes mostly regulate neurotransmitter receptor function and synaptic vesicle exocytosis.

From: Synaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins

Fig. 4: Differentially expressed synaptic genes mostly regulate neurotransmitter receptor function and synaptic vesicle exocytosis.

a Clustering of the coefficients of correlation for RNA expression of up-regulated synaptic genes in excitatory neuron types from the hippocampal formation. b Sunburst chart showing SynGO Cellular Component terms enriched among synaptic genes that present increased expression in one or two types of excitatory neurons from the hippocampal formation. The background set for this analysis was our synaptic reference proteome. Maximum stringency was applied for evidence filtering of SynGO annotations. PM plasma membrane, AZ active zone and PSD postsynaptic density. c Sunburst chart showing SynGO Biological Process terms enriched among genes expressed at synapses that present increased expression in one or two types of excitatory neurons from the hippocampal formation. d Classes and types of excitatory neurons presenting increased expression of genes within Biological Process (GO) terms overrepresented in the SynGO analysis.

Back to article page