Table 4 Regional comparison of combined genetic risk and prevalence of haemochromatosis in white British across England

From: The landscape of hereditary haemochromatosis risk and diagnosis across the British Isles and Ireland

Region

Prevalence (%)

Genetic risk (%)

Ratio

Cheshire & Merseyside

0.345

0.542

1.57

London

0.195

0.376

1.93

E-Midlands

0.157

0.388

2.48

Manchester

0.214

0.532

2.49

W-Midlands

0.162

0.421

2.60

Southwest

0.131

0.356

2.72

East

0.133

0.364

2.74

Cornwall

0.159

0.441

2.78

Yorkshire

0.167

0.467

2.79

Lancashire & S Cumbria

0.188

0.525

2.80

Southeast

0.130

0.366

2.82

North

0.160

0.519

3.24

Birmingham

0.127

0.427

3.36

  1. Prevalence is the raw prevalence in each region; genetic risk is calculated as the product of the penetrances and genotype frequencies, summed for p.Cys282Tyr homozygotes and p.Cys282Tyr/p.His63Asp heterozygotes; both are given as %. Penetrances for males were used for this calculation.
Back to article page