Fig. 6: SORCS2 is present both in neurons and astrocytes in aged PDAPP mice. | Nature Communications

Fig. 6: SORCS2 is present both in neurons and astrocytes in aged PDAPP mice.

From: Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease

Fig. 6

Representative images from the total of 3 animals per genotype of dentate gyrus (a) and cortex (b) in the brain sections from 40 weeks old female PDAPP/WT and PDAPP/KO mice immunostained for SORCS2 (green) and markers of astrocytes (S100β, upper panels, red) and neurons (NeuN, lower panels, red). DAPI was used to stain cell nuclei (blue). Brain regions imaged in panels (a) and (b) are marked in the schemes above. Arrowheads point to SORCS2-positive astrocytes. White boxes in the PDAPP/WT images indicate the area magnified in the panels given to the right. Scale bar: 50 µm, in insets: 10 µm.

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