Fig. 1: Identified FOS/FOSB fusion cases in the Yale discovery cohort.
From: Subgroup of meningiomas involving FOS and FOSB gene fusions
a–d (left panels), Magnetic resonance imaging (MRI) and circos plots depicting the fusion events for patients MN-70001, MN-52391, MN-70002, and MN-70003 (a-d respectively). The MRI panels demonstrate axial T1 post-contrasted images with the tumor depicted by the red asterisk (left); corresponding fluid attenuated inversion recovery (FLAIR) sequences (center) reveal minimal, if any, edema associated with all tumors. The right image is another plane of T1 post-contrasted sequence. a–d (right panels), Circos plots displaying FOS-SLC4A4 a (right panel), and LMNA-FOSB fusions b–d (right panels). Circos plot outer tracks represent the chromosomes, gene labels, and points indicate somatic SNV/INDELs identified, orange: loss of function, blue: missense. Links are the breakpoints identified for the fusion events.
