Table 2 Mean difference (95% CI) in neurocognitive z-score associated with the second or third tertile of PCPhenoAge EAA compared to the first tertile stratified by exposure to CNS-directed therapy
Non-CNS-treateda n = 663 | CNS-treatedb n = 750 | |||||||
|---|---|---|---|---|---|---|---|---|
Tertile 2 vs. 1 | Tertile 3 vs. 1 | Tertile 2 vs. 1 | Tertile 3 vs. 1 | |||||
β (95% CI) | p* | β (95% CI) | p* | β (95% CI) | p* | β (95% CI) | p* | |
Global cognition | ||||||||
Verbal reasoning | 0.01 (−0.19, 0.21) | 0.973 | −0.13 (−0.33, 0.07) | 0.199 | −0.15 (−0.33, 0.04) | 0.210 | −0.29 (−0.49, −0.09) | 0.013 |
Non-verbal reasoning | −0.03 (−0.17, 0.12) | 0.973 | −0.22 (−0.36, −0.07) | 0.013 | −0.07 (−0.23, 0.09) | 0.395 | −0.18 (−0.35, −0.01) | 0.051 |
Academics | ||||||||
Word reading | −0.002 (−0.11, 0.11) | 0.973 | −0.09 (−0.20, 0.02) | 0.129 | −0.09 (−0.21, 0.02) | 0.210 | −0.17 (−0.29, −0.05) | 0.013 |
Mathematics | −0.10 (−0.27, 0.07) | 0.973 | −0.16 (−0.33, 0.01) | 0.129 | −0.13 (−0.30, 0.05) | 0.210 | −0.17 (−0.36, 0.01) | 0.068 |
Attention | ||||||||
Sustained | 0.13 (−0.08, 0.34) | 0.478 | −0.15 (−0.36, 0.06) | 0.316 | −0.05 (−0.27, 0.16) | 0.799 | −0.14 (−0.37, 0.09) | 0.325 |
Variability | 0.001 (−0.21, 0.21) | 0.990 | −0.18 (−0.39, 0.03) | 0.316 | −0.10 (−0.29, 0.10) | 0.799 | −0.16(−0.37, 0.05) | 0.325 |
Commissions | 0.09 (−0.11, 0.28) | 0.520 | −0.07 (−0.26, 0.13) | 0.504 | 0.06 (−0.13, 0.25) | 0.799 | −0.08 (−0.28, 0.11) | 0.408 |
Focused attention | −0.12 (−0.31, 0.08) | 0.478 | −0.10 (−0.29, 0.09) | 0.406 | −0.03 (−0.23, 0.18) | 0.799 | −0.14 (−0.35, 0.08) | 0.325 |
Processing Speed | ||||||||
Visual-motor | 0.01 (−0.16, 0.18) | 0.888 | −0.19 (−0.36, −0.02) | 0.049 | −0.07 (−0.24, 0.11) | 0.808 | −0.10 (−0.28, 0.08) | 0.590 |
Motor | 0.07 (−0.15, 0.28) | 0.888 | −0.01 (−0.22, 0.20) | 0.921 | 0.03 (−0.18, 0.23) | 0.808 | −0.02 (−0.23, 0.20) | 0.867 |
Memory | ||||||||
Span | 0.17 (−0.02, 0.36) | 0.289 | −0.14 (−0.32, 0.05) | 0.560 | −0.08 (−0.25, 0.09) | 0.350 | −0.10 (−0.28, 0.08) | 0.284 |
New verbal encoding | 0.05 (−0.16,0.25) | 0.850 | −0.06 (−0.26, 0.14) | 0.771 | −0.14 (−0.34, 0.06) | 0.248 | −0.20 (−0.42, 0.01) | 0.234 |
Short-term verbal recall | −0.10 (−0.30, 0.10) | 0.649 | −0.10 (−0.30, 0.09) | 0.579 | −0.13 (−0.32, 0.06) | 0.248 | −0.14 (−0.34, 0.07) | 0.257 |
Long-term verbal recall | −0.01 (−0.21, 0.19) | 0.920 | −0.03 (−0.23, 0.17) | 0.784 | −0.16 (−0.36, 0.05) | 0.248 | −0.18 (−0.40, 0.04) | 0.234 |
Executive function | ||||||||
Perseveration | 0.13 (−0.10, 0.35) | 0.801 | −0.14 (−0.36, 0.09) | 0.226 | 0.01 (−0.23, 0.24) | 0.964 | −0.01 (−0.26, 0.25) | 0.968 |
Working memory | 0.08(−0.10,0.25) | 0.801 | −0.14 (−0.31, 0.04) | 0.226 | 0.03 (−0.13, 0.19) | 0.915 | −0.07 (−0.24, 0.10) | 0.540 |
Cognitive switching/flexibility | 0.004 (−0.24, 0.25) | 0.973 | −0.19 (−0.44, 0.05) | 0.226 | −0.19 (−0.45, 0.07) | 0.584 | −0.27 (−0.55, 0.00) | 0.207 |
Verbal fluency | 0.01 (−0.20, 0.23) | 0.973 | −0.13 (−0.34, 0.07) | 0.226 | −0.06 (−0.24, 0.12) | 0.915 | −0.15 (−0.35, 0.04) | 0.232 |
