Fig. 8: Proposed mechanism of microbiota-mediated regulation of intestinal P-gp. | Nature Communications

Fig. 8: Proposed mechanism of microbiota-mediated regulation of intestinal P-gp.

From: Odoribacter splanchnicus rescues aging-related intestinal P-glycoprotein damage via GDP-L-fucose secretion

Fig. 8

Aging induces gut microbiota dysbiosis characterized by depletion of Odoribacter splanchnicus (O. splanchnicus), leading to reduced intestinal P-gp (ABCB1) expression and impaired xenobiotic efflux. O. splanchnicus encodes GDP-mannose 4, 6-dehydratase (GMDS) and GDP-L-fucose synthase (TSTA3), which mediate microbial biosynthesis of GDP-L-fucose. GDP-L-fucose acts on intestinal epithelial cells to promote phosphorylation of eukaryotic translation initiation factor 4E (eIF4E), thereby activating c-Jun–driven transcription of ABCB1 and enhancing P-gp expression. This microbiota–metabolite–transporter signaling axis preserves intestinal detoxification capacity, and its disruption contributes to age-associated decline in P-gp function. Created by figdraw.com (Copyright Code: ARORA33111).

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