Fig. 2: Fibroblasts are the strongest immune signalers in HS by scRNAseq meta-analysis. | Nature Communications

Fig. 2: Fibroblasts are the strongest immune signalers in HS by scRNAseq meta-analysis.

From: Plastic associated endocrine disruptors reduce Nicastrin protein and potentiate inflammation in hidradenitis suppurativa skin disease

Fig. 2

a After filtering and normalization of two HS datasets (GSE15477525 and GSE17599023), cells from HS and CNTRL samples cluster into 18 cell identities; fibroblasts are indicated in blue and circled in red. b CXCL and CCL signaling is significantly elevated in fibroblasts. c Fibroblast originating CXCL and CCL signals are dominant and signal to plasma cells and CD8 + T cells as visualized in a chord diagram. d Among all signaling pathways (left) as well as CXCL and CCL specifically (right), fibroblasts are the most prolific senders of signals, while receiving relatively little immune signals. e Fibroblasts rank as the strongest senders of CXCL and CCL immune signaling. f After siRNA knockdown of NCSTN, fibroblasts demonstrate a larger fold change of affected genes than keratinocytes in bulk RNA seq (n = 5). Source data are provided as a Source Data file.

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