Fig. 1: Anti-tumour mechanism of PfCC.
1. The main steps were as follows: 1. PfCC was synthesized. under the acidic tumour microenvironment (pH 6.5), the cobalt-based platform could degrade and release free Co2+ to react with H2S, which initially reduced the H2S levels in the tumour, and alleviated the occurrence of intestinal inflammation. 2. PfCC actively targeted orthotopic CRC, and with the reaction of in situ H2S, a precipitate with colorectal photothermal effect was generated to accurately killing tumour cells. 3. The antimicrobial peptide, modified on the CRC cell membrane, could effectively be released through the disintegration of the cobalt-based structure, and synergistically regulated intestinal flora with reducing the harm of Desulfovibrio and other bacteria, and then resulting in promoting the growth of beneficial bacteria. 4. Based on the large model algorithm, the size and number of CRC tumours were quantitatively analysed, and the real-time dynamic quantification of the therapeutic effect of PfCC also could be realized. The 3D element of Fig. 1 was created with 3D Max, and assembled with CorelDraw.
