Fig. 1: Manhattan plot of brain age gap in females.
From: No causal links between estradiol and female’s brain and mental health using Mendelian randomization
The blue/lower and red/upper lines indicate the suggestive (p < 5 × 10−5) and the genome-wide significance (p < 5 × 10−8; i.e., accounting for multiple comparisons) thresholds, respectively. The genome-wide association study was run using the standard additive model of linear associations. Source data are provided as a Source Data file.
