Fig. 1: Unbiased data analysis reveals platelets display distinct type-III specific phenotype.
From: Single cell mapping identifies a distinct platelet-phenotype in psoriatic type III inflammation
a Schematic overview over study design. Psoriasis (pso) and atopic dermatitis (AD) patients were prospectively followed from baseline, to one month post systemic therapy (Tx) initiation (T1), to 16 weeks post systemic therapy initiation (T4). At each timepoint, platelets were purified from whole blood and subjected to spectral flow cytometry analysis. Created in BioRender. Heikenwälder, M. (2025) https://BioRender.com/jvyk1jp. b Unbiased principal component (PC) analysis of the total portion of analyzed platelets from the complete cohort 1. c Scree plot of principal component analysis (PCA) on mean fluorescence intensity (MFI) data of all platelets at baseline. d Heatmap depicting the contribution of the individual markers of the first two components of the PC Analysis. Visualization of the data, stratified by timepoint into baseline (e), T1 (f) and T4 (g), using Uniform Manifold Approximation and Projection (UMAP), and subsequently clustered using FlowSOM. Data shown represents the analysis of cohort 1 (n = 10 controls, n = 27 psoriasis patients, n = 4 AD patients), which was processed, measured and analyzed in one batch. Source data are provided in a source data file.
