Fig. 1: Structural comparison of HTLV-1 CANTD and HIV-1 CANTD.
From: The Human T-cell Leukemia Virus capsid protein is a potential drug target
a The HTLV-1 CANTD1-127 is labelled with secondary structure elements, including a β-hairpin (pale purple) formed by β-strands 1 and 2, α-helices 1-7, and an additional 310 helix between α4 and α5, a 90° rotated view shown at the bottom. b HTLV-1 CANTD is superposed onto HIV-1 CANTD (PDB 4XFX, in pale cyan). In HIV-1, the CypA binding loop and α6 are highlighted by the grey shadow with magnified views shown inset. c–e HTLV-1 CANTD is superposed onto HIV-1 CANTD with open (PDB 5HGL) and closed (PDB 5HGN) states of β-hairpin, showing the residue interactions in the magnified views (inset).
