Fig. 2: Features of HTLV-1 CANTD hexagonal lattice and interaction interfaces.
From: The Human T-cell Leukemia Virus capsid protein is a potential drug target
a Within the hexagonal crystal form, the HTLV-1 CANTD structure generates a hexamer that extends into a hexagonal lattice by crystallographic 6-fold symmetry (b). c The intra-hexamer interface reveals the interaction between two NTD subunits, with relevant residues displayed as sticks. d The trimeric interface among three inter-hexamers is formed by α-helices 4, with relevant residues shown as sticks. e HTLV-1 CANTD hexamer contains six lysine residues at position 18, forming a positively charged pore at the centre of the hexamer with a diameter of 20.2 Å. f HIV-1 CANTD hexamer (PDB 5HGL) has an arginine ring at position 18 with a diameter of 16.2 Å. HTLV-1 CANTD and HIV-1 CANTD are shown on the same scale, with the diameter measured from Cα to Cα.
