Fig. 1: The five classes of endocrine circuits and their dynamic response to brief and prolonged input stimuli. | Nature Communications

Fig. 1: The five classes of endocrine circuits and their dynamic response to brief and prolonged input stimuli.

From: Unifying regulatory motifs in endocrine circuits

Fig. 1

Diagrams are generic and stimulation and inhibition may be exchanged. a−e Class 1−5, respectively. Metabolite, hormone and gland mass dynamics from simulations with a brief input pulse of 9 days (dashed blue line) or a prolonged pulse of 150 days and a second prolonged pulse with twice the amplitude at day 350 (orange line). Constant tissue in class 2 indicates that the secreting cell type growth is not regulated by elements in the circuit. The functions of the circuits are summarized. Simulation parameters are \(q={q}_{3}=16\,{da}{y}^{-1}\), \({q}_{1}=288\,{da}{y}^{-1}\), \({q}_{2}=48\,{da}{y}^{-1}\), \({r}_{{Classes}1-3}={r}_{3}=16\,{da}{y}^{-1}\), \({r}_{1}=288\,{da}{y}^{-1}\), \({r}_{{Class}4}={r}_{2}=48\,{da}{y}^{-1}\), \(c={c}_{1}={c}_{2}=d={d}_{1}={d}_{2}=1/15\,{da}{y}^{-1}\), \(s=48\,{da}{y}^{-1}\), \(a=16\,{da}{y}^{-1}\) (Box 1, Methods).

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