Fig. 4: Mendelian randomization estimates of factors in relation to coronary heart disease risk.

Causal estimates were generated using the inverse variance-weighted method after removing outliers. The dashed line represents the threshold after multiple testing correction (Bonferroni correction, p value < 2.35 × 10−04). Two-sided statistical tests were performed. Dots represent ln (odds ratios). A set of the highest-risk factors was annotated. Source data are provided as a Source data file (Supplementary Data 7).