Fig. 5: Risk of incident coronary heart disease according to categories of eight domains within each age group.

The favorable profile was set as a reference in each domain. The associations were estimated using a Cox proportional hazards regression model that included all eight domains, mutually adjusted, and with adjustments for baseline age, sex, ethnic background, family history of cardiovascular disease, and assessment center. The points represent hazard ratios (HR), and the horizontal lines represent the corresponding 95% confidence interval (CI). Two-sided statistical tests were used. N number of individuals at risk, n number of CHD cases. Source data are provided as a Source data file (Supplementary Data 8).