Table 1 Risk of incident coronary heart disease according to the categories of the eight domains

From: Modifiable influencing factors and their joint effects on early- and late-onset coronary heart disease

Domains

n/N

HR

p value

p for trend

Socioeconomic status

    

 Favorable

6905/136,714

1.00 (Reference)

-

 

 Intermediate

9399/140,380

1.06 (1.03, 1.09)

3.57 × 10−04

1.04 × 10−32

 Unfavorable

11,288/117,485

1.21 (1.17, 1.26)

1.52 × 10−29

 

Lifestyles

    

 Favorable

6828/131,527

1.00 (Reference)

-

 

 Intermediate

8717/131,526

1.11 (1.07, 1.15)

2.35 × 10−10

1.80 × 10−72

 Unfavorable

12,047/131,526

1.33 (1.29, 1.37)

6.93 × 10−66

 

Early life factors

    

 Favorable

9013/132,366

1.00 (Reference)

-

 

 Intermediate

9267/132,742

1.00 (0.97, 1.03)

9.96 × 10−01

6.61×10−03

 Unfavorable

9312 /129,471

1.04 (1.01, 1.07)

1.05 × 10−02

 

Psychosocial factors

    

 Favorable

7701/131,538

1.00 (Reference)

-

 

 Intermediate

9056/131,668

0.98 (0.95, 1.01)

1.25 × 10−01

5.47 × 10−06

 Unfavorable

10,835/131,373

1.06 (1.03, 1.10)

8.43 × 10−05

 

Local environment

    

 Favorable

8899/132,918

1.00 (Reference)

-

 

 Intermediate

9515/130,137

1.05 (1.01, 1.08)

3.58 × 10−03

1.66 × 10−02

 Unfavorable

9178/131,524

1.04 (1.00, 1.07)

2.96 × 10−02

 

Blood assays

    

 Favorable

5010/131,527

1.00 (Reference)

-

 

 Intermediate

8213/131,526

1.20 (1.16, 1.25)

2.68 × 10−24

1.53 × 10−205

 Unfavorable

14,369/131,526

1.65 (1.59, 1.70)

2.41 × 10−177

 

Physical measures

    

 Favorable

7210/131,527

1.00 (Reference)

-

 

 Intermediate

8686/132,932

1.11 (1.07, 1.14)

1.81 × 10−09

4.89 × 10−62

 Unfavorable

11,696/130,120

1.34 (1.29, 1.39)

1.81 × 10−58

 

Health and medical history

    

 Favorable

5512/131,836

1.00 (Reference)

-

 

 Intermediate

7858/131,217

1.24 (1.20, 1.28)

6.89 × 10−33

1.03 × 10−267

 Unfavorable

14,222/131,526

1.78 (1.72, 1.84)

7.78 × 10−239

 
  1. The favorable profile was set as a reference in each domain. The associations were estimated using a Cox proportional hazards regression model that included all eight domains, mutually adjusted, and with adjustments for baseline age, sex, ethnic background, family history of cardiovascular disease, and assessment center. Two-sided statistical tests were used.
  2. N number of individuals at risk, n number of CHD cases.