Fig. 5: Topological changes within the five topological epochs of life.
a Schematic showing the ranges of each epoch across the lifespan. To the left of the schematic, per epoch, the metric with the highest LASSO coefficient (Ī²), indicating the strongest predictor of age, is shown. On the right side of the schematic, next to each epoch, the metric with the largest correlation (r) is displayed, highlighting the strongest directional changes across age. For the epochs in which the driving factor and strongest directional change are the same, the metrics are highlighted in gray. The combination plots show all the regularized LASSO coefficients in a bar graph (left y-axis) and the correlations as a scatter plot (right y-axis) for (b) epoch 5, (c) epoch 4, (d) epoch 3, (e) epoch 2, and (f) epoch 1. Red scatter points indicate Pearson correlations with pā<ā0.05. Dotted gray lines highlight zero on the correlation axis.
