Fig. 1: Flowchart of inclusion and metabolomic score derivation methodology. | Nature Communications

Fig. 1: Flowchart of inclusion and metabolomic score derivation methodology.

From: Plasma metabolomic signature of breastfeeding and risk of cardiometabolic diseases

Fig. 1: Flowchart of inclusion and metabolomic score derivation methodology.The alternative text for this image may have been generated using AI.

We investigated associations of total duration of breastfeeding across all pregnancies with plasma metabolites using high-throughput metabolomics in two well-characterized cohorts of middle-aged to older women (Nurses’ Health Studies, NHS & NHSII), and derived a metabolite-based breastfeeding score and replicated this score in an independent cohort of postmenopausal women (Women’s Health Initiative, WHI). We further investigated the prospective associations of metabolite-based breastfeeding score with the risk of type II diabetes and cardiovascular disease. Results were externally replicated in the PREvención con DIeta MEDiterránea (PREDIMED) trial and the WHI cohort.

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