Table 1 Baseline participants characteristics from NHS, NHSII, WHI and PREDIMED cohorts
From: Plasma metabolomic signature of breastfeeding and risk of cardiometabolic diseases
Participants characteristics | NHS N = 2404 | NHSII N = 1772 | WHI N = 2088 | PREDIMED N = 995† |
|---|---|---|---|---|
Age at blood draw, years | 57.1 (6.79) | 44.8 (4.40) | 67.0 (6.83) | 67.8 (5.6) |
White participants | 2363 (98.3%) | 1732 (97.7%) | 1670 (80.0%) | 964 (96.9%) |
Age at 1st birth, years | ||||
<20 | 12 (0.5%) | 112 (6.3%) | 352 (16.9%) | -- |
20-29 | 2154 (89.6%) | 1238 (69.9%) | 1275 (61.1%) | -- |
30+ | 238 (9.9%) | 394 (22.2%) | 161 (7.7%) | -- |
Pre-pregnancy BMI, kg/m2 | 21.4 (2.96) | 20.8 (2.69) | -- | -- |
BMI at blood collection, kg/m2 | 26.2 (4.84) | 25.4 (5.48) | -- | -- |
Family history of CVD | 537 (22.3%) | 455 (25.7%) | 1477 (70.7%) | 311 (31.3%) |
Family history of T2D | 829 (34.5%) | 529 (29.9%) | -- | -- |
Smoking status | ||||
Current | 331 (13.8%) | 131 (7.4%) | 232 (11.1%) | 74 (7.4%) |
Never | 1151 (47.9%) | 1196 (67.5%) | 994 (47.6%) | 851 (85.5%) |
Past | 915 (38.1%) | 445 (25.1%) | 837 (40.1%) | 70 (7.0%) |
Physical activity, MET-h/week | 15.2 (21.2) | 17.7 (23.7) | 10.9 (12.6) | 3.1 (2.8) |
Alcohol intake, g/d | 5.97 (10.7) | 3.66 (6.81) | 4.56 (10.8) | 3.7 (6.7) |
Parity, n‡ | ||||
1 | 163 (6.8%) | 285 (16.1%) | 187 (9.0%) | -- |
2 | 699 (29.1%) | 853 (48.1%) | 496 (23.8%) | -- |
3 | 697 (29.0%) | 484 (27.3%) | 521 (25.0%) | -- |
4+ | 845 (35.1%) | 150 (8.5%) | 829 (39.7%) | -- |
Aspirin use | 1725 (71.8%) | 704 (39.7%) | 564 (27.0%) | 139 (14.0%) |
Menopausal status | ||||
Missing/dubious | 240 (10.0%) | 177 (10.0%) | 0 | 0 |
Postmenopausal but not on PMH | 954 (39.7%) | 33 (1.9%) | 1435 (68.8%) | 963 (98.2%) |
Postmenopausal on PMH | 777 (32.3%) | 182 (10.3%) | 653 (31.2%) | 18 (1.8%) |
Premenopausal | 433 (18.0%) | 1380 (77.9%) | 0 | 0 |
Fasting ≥ 8 hrs at blood draw | 2104 (87.5%) | 1265 (71.4%) | 2088 (100%) | 995 (100%) |
