Fig. 3: Mefloquine potentiates PANX1 channel activity.
From: Structural basis of PANX1 permeation and positive modulation by mefloquine
a Current-voltage relationships of non-transfected tsA201 cells (left, n = 6) and cells overexpressing wild-type (WT) PANX1 (right, n = 7) pre- and post-perfusion with 150 µM mefloquine in the bath solution. Circles represent mean current, and error bars represent s.e.m. Here and below, n represents the number of independent cells recorded in whole-cell patch clamp experiments. b Voltage-conductance relationships of tsA201 cells overexpressing wild-type PANX1 before and after perfusion with 150 µM mefloquine in the bath solution (n = 7). Circles represent mean, and error bars represent s.e.m. c Cryo-EM maps (left) and atomic model (right) of PANX1 with mefloquine (EMD-70769 and 9OQP). The structures are viewed parallel to the membrane. The mefloquine density is colored in green. The location of the side tunnel is also indicated. The cryo-EM map is C7 refined and are contoured at 6σ level.
