Fig. 6: Masp3 deficiency resulted in spatial working memory deficits. | Nature Communications

Fig. 6: Masp3 deficiency resulted in spatial working memory deficits.

From: A spatial atlas of the complement system uncovers unique expression patterns in postnatal brain development in mice

Fig. 6

A Body weight of 13–14-week-old adult Masp3+/+ (n = 6 females, 20.45 g ± 1.45 g; n = 8 males, 25.93 g ± 1.72 g), Masp3+/− (n = 4 females, 20.23 g ± 0.85 g; n = 9 males, 26.17 g ± 1.53 g) and Masp3−/− (n = 3 females, 17.47 g ± 0.68 g; n = 7 males, 20.71 g ± 1.10 g) mice. Two-way ANOVA with Tukey’s multiple comparisons test. B Illustration of spatial novelty Y-maze test setup, created with BioRender.com. C Representative heatmap of spatial novelty Y-maze during test phase in which the left arm was novel, in Masp3+/+ (left panel), Masp3+/− (middle panel) and Masp3−/− (right panel) mice. D Time spent and E distance run in the familiar (black dots) vs. novel (red triangles) arm in spatial novelty Y-maze test. Masp3+/+: n = 8 (familiar arm: 37.86 s ± 16.99 s, 244 cm±86.78 cm; novel arm: 62.54 s ± 18.70 s, 373.50 cm±124.238 cm); Masp3+/−: n = 9 (familiar arm: 39.55 s ± 8.14 s, 222.49 cm ± 62.81 cm; novel arm: 63.96 s ± 8.51 s, 378.03 cm ± 60.80 cm); Masp3−/−: n = 7 (familiar arm: 50.91 s ± 15.19 s, 282.08 cm±104.73 cm; novel arm: 49.13 s ± 13.48 s, 342.15 cm ± 91.69 cm); all male mice. Paired two-way ANOVA followed by Sidak’s test for multiple comparison. Error bars represent standard deviation; ns not significant; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Source data are provided as a Source Data File.

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