Table 1 Hazard ratios for the association between psychological distress and all-cause mortality after adjustment for each mediator

From: Mediators of the association between psychological distress and mortality in people diagnosed with cancer

 

UK Biobank

FPS

Model 2

Adjusted HRs (95% CI)

-

Adjusted HRs (95% CI)

-

 

1.43 (1.23–1.67)

-

1.72 (1.44–2.07)

-

Model 2 + cancer stage

Adjusted HRs (95% CI)

-

Adjusted HRs (95% CI)

% of attenuation

 

-

-

1.56 (1.29–1.88)

22.2

Model 2 + mediator

Adjusted HRs (95% CI)

% of attenuation

Adjusted HRs (95% CI)

% of attenuation

Inflammation

1.35 (1.15–1.57)

18.6

-

-

Fruit

1.42 (1.22–1.66)

2.3

-

-

Vegetables

1.43 (1.23–1.67)

0.0

-

-

Red meat

1.43 (1.23–1.67)

0.0

-

-

Processed meat

1.43 (1.23–1.67)

0.0

-

-

Physical activity

1.40 (1.20–1.63)

7.0

1.68 (1.40–2.02)

5.6

BMI

1.44 (1.23–1.67)

0.0

1.73 (1.44–2.08)

0.0

Alcohol

1.42 (1.22–1.66)

2.3

1.73 (1.44–2.08)

0.0

Smoking

1.36 (1.17–1.59)

16.3

1.71 (1.43–2.06)

1.4

Sleep quality

1.42 (1.21–1.65)

2.3

1.70 (1.40–2.06)

2.8

Sleep duration

1.39 (1.19–1.62)

9.3

1.75 (1.45–2.11)

0.0

  1. Cox proportional hazards models (two-tailed).
  2. CI = 95% confidence interval.
  3. All models adjusted for age, sex, ethnicity, education, number of comorbidities, age at cancer diagnosis, time between cancer diagnosis and depressive symptoms assessment, and antidepressant medication (yes/no).
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