Fig. 4: Synthesis of hapmnioide A (1) and haploide O (2).

a Divergent total synthesis of hapmnioide A (1) and haploide O (2) from the common intermediate 8. b Optimization of reaction conditions for pivotal 1,2-acyl migration. TBAF tetrabutylammonium fluoride, KHMDS potassium bis(trimethylsilyl)amide, rt room temperature.