Fig. 4: Microbiome-associated loci. | Nature Communications

Fig. 4: Microbiome-associated loci.

From: Genetic architecture and mechanisms of host-microbiome interactions from a multi-cohort analysis of outbred laboratory rats

Fig. 4: Microbiome-associated loci.The alternative text for this image may have been generated using AI.

This porcupine plot shows the association values for all microbiome phenotypes (n = 2294 phenotypes from four cohorts). The lower line (−logP = 5.8) reflects the genome-wide significance threshold for an individual trait, which accounts for the number of independent SNPs tested; the higher line (−logP = 8.4) is the adjusted significance threshold, which, in addition, accounts for the number of independent microbiome phenotypes examined in a cohort. The larger, coloured dots highlight genome-wide significant associations for microbiome phenotypes that have an annotation at the genus level. The colour of the dot refers to the genus affected. The shape of the dot refers to the cohort in which the association was identified.

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